A proactive noise suppression system and method for a power supply network of an integrated circuit. The system and method include receiving an IC event sequence to a memory element, correlating the IC event sequence to a storage location in a second memory element, the storage location including an anti-noise response signature, and utilizing the anti-noise response signature to proactively generate an anti-noise response in a power supply network in at least a portion of the integrated circuit at about the time of execution of the first IC event sequence. Anti-noise response signatures may be adaptively updated and/or created based on noise measurements made corresponding to execution of an IC event sequence by the integrated circuit.