A direction-free spray brush includes an applicator body, which defines an accommodation chamber and holds a brush at the front side and a spray tube in the brush, an accumulation tube connected to the spray tube and having an accumulation chamber and a side hole in communication between the accumulation chamber and the accommodation chamber for guiding a powder substance from the accommodation chamber into the accumulation chamber, and an air inflator, which has an air guide connected to the accumulation chamber of the accumulation tube and an inflation bulb fastened to the air guide for pumping air through the air passage in the air guide into the accumulation chamber to force the powder substance from the accumulation chamber through the spray tube into the brush for application.