发明授权
- 专利标题： Prodrugs of CGRP receptor antagonists
- 专利标题（中）： CGRP受体拮抗剂的前药
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申请号： US12864120申请日： 2009-02-04
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公开(公告)号： US08080544B2公开(公告)日： 2011-12-20
- 发明人: Ian M. Bell , Steven N. Gallicchio , Valentino J. Stella
- 申请人： Ian M. Bell , Steven N. Gallicchio , Valentino J. Stella
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Gerard M. Devlin; Raynard Yuro
- 国际申请： PCT/US2009/033008 WO 20090204
- 国际公布： WO2009/100090 WO 20090813
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; A61P25/06 ; C07D471/04
摘要：
Disclosed are prodrug compounds of formula (I) (wherein variables R1 and R2 are as described herein) which are analogues of an antagonist of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
公开/授权文献
- US20100298269A1 PRODRUGS OF CGRP RECEPTOR ANTAGONISTS 公开/授权日：2010-11-25
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