发明授权
US08080559B2 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin and its preparation and use for the treatment of cancer
失效
5（S） - （2'-羟基乙氧基）-20（S） - 喜树碱及其制备及用于治疗癌症
- 专利标题： 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin and its preparation and use for the treatment of cancer
- 专利标题（中）： 5（S） - （2'-羟基乙氧基）-20（S） - 喜树碱及其制备及用于治疗癌症
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申请号： US12577399申请日： 2009-10-12
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公开(公告)号： US08080559B2公开(公告)日： 2011-12-20
- 发明人: Venkateswarlu Akella , Shanavas Alikunju , Ajaya Kumar Reka , Ramesh Mullangi , Raju Sirisilla , Subrahmanyam Duvvuri , Sriram Rajagopal
- 申请人： Venkateswarlu Akella , Shanavas Alikunju , Ajaya Kumar Reka , Ramesh Mullangi , Raju Sirisilla , Subrahmanyam Duvvuri , Sriram Rajagopal
- 申请人地址： IN Hyderabad, Andhra Pradesh US NJ Bridgewater
- 专利权人： Dr. Reddy's Laboratories Limited,Dr. Reddy's Laboratories, Inc.
- 当前专利权人： Dr. Reddy's Laboratories Limited,Dr. Reddy's Laboratories, Inc.
- 当前专利权人地址： IN Hyderabad, Andhra Pradesh US NJ Bridgewater
- 代理商 Balaram Gupta; Robert A. Franks; Thomas C. McKenzie
- 优先权： IN897/CHE/2006 20060524
- 主分类号： A61K31/4745
- IPC分类号： A61K31/4745 ; C07D491/22
摘要：
A 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin diasterisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2′-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2′-hydroxyethoxy)-20(S)-camptothecin diastereoisomer. Pharmaceutical compositions of the 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin diastereoisomer are also described as are methods of using the compound for the inhibition of topoisomerase I and for the treatment of cancer.
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