发明授权
- 专利标题： Human monoclonal antibodies to activin receptor-like kinase-1
- 专利标题（中）： 人类激活素受体样激酶-1的单克隆抗体
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申请号： US12402854申请日： 2009-03-12
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公开(公告)号： US08080646B2公开(公告)日： 2011-12-20
- 发明人: Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Shelly Sims Belouski , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , Sirid Aimee Kellerman , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
- 申请人： Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Shelly Sims Belouski , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , Sirid Aimee Kellerman , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
- 申请人地址： US CA Fremont US NY New York
- 专利权人： Amgen Fremont, Inc.,Pfizer Inc.
- 当前专利权人： Amgen Fremont, Inc.,Pfizer Inc.
- 当前专利权人地址： US CA Fremont US NY New York
- 代理机构： Ropes & Gray LLP
- 代理商 Jane T. Gunnison; Z. Ying Li
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12N15/74 ; C12N5/10
摘要：
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.