A fluid delivery system for use with an endoscope. Certain embodiments of the invention include a single, large fluid source and pump installed upon an operator console, in combination with a small fluid reservoir and pump installed within a proximal connector of the imaging endoscope, multiple fluid sources that feed a common fluid channel that are pressurized by a common pump, multiple fluid sources that feed dedicated fluid channels that are pressurized by dedicated pumps, and a small fluid reservoir and pump installed within a handheld manual controller of the imaging endoscope. The fluid delivery endoscopic systems of the present invention provide the user with the flexibility of changing fluids either in advance of a procedure or on-the-fly as needed, instead of relying on fixed fluid sources only.