发明授权
- 专利标题： Dual pharmacophores—PDE4-muscarinic antagonistics
- 专利标题（中）： 双重药效学 - PDE4-毒蕈碱拮抗剂
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申请号： US12365930申请日： 2009-02-05
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公开(公告)号： US08084449B2公开(公告)日： 2011-12-27
- 发明人: James Francis Callahan , Guoliang Lin , Zehong Wan , Hongxing Yan
- 申请人： James Francis Callahan , Guoliang Lin , Zehong Wan , Hongxing Yan
- 申请人地址： GB Greenford, Middlesex
- 专利权人： Glaxo Group Limited
- 当前专利权人： Glaxo Group Limited
- 当前专利权人地址： GB Greenford, Middlesex
- 代理商 Robert J. Smith
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; A61K31/551 ; A61K31/437 ; C07D487/04
摘要：
The present invention is directed to novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions and their use as dual chromaphores having inhibitory activity against PDE4 and muscarinic acetylcholine receptors (mAChRs), and thus being useful for treating respiratory diseases.
公开/授权文献
- US20090203657A1 Dual Pharmacophores - PDE4-Muscarinic Antagonistics 公开/授权日：2009-08-13
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