发明授权
- 专利标题: Process for preparing tetrahydroquinoline derivatives
- 专利标题(中): 制备四氢喹啉衍生物的方法
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申请号: US12295618申请日: 2007-03-29
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公开(公告)号: US08084611B2公开(公告)日: 2011-12-27
- 发明人: Masaki Okamoto , Akira Sakuragi , Yoshikazu Mori , Takeshi Hamada , Hitoshi Kubota , Yoshinori Nakamura , Takanori Higashijima , Norimitsu Hayashi
- 申请人: Masaki Okamoto , Akira Sakuragi , Yoshikazu Mori , Takeshi Hamada , Hitoshi Kubota , Yoshinori Nakamura , Takanori Higashijima , Norimitsu Hayashi
- 申请人地址: JP Osaka
- 专利权人: Mitsubishi Tanabe Pharma Corporation
- 当前专利权人: Mitsubishi Tanabe Pharma Corporation
- 当前专利权人地址: JP Osaka
- 代理机构: Birch, Stewart, Kolasch & Birch, LLP
- 优先权: JP2006-092783 20060330; JP2006-322845 20061130
- 国际申请: PCT/JP2007/057610 WO 20070329
- 国际公布: WO2007/116922 WO 20071018
- 主分类号: C07D215/38
- IPC分类号: C07D215/38
摘要:
The present invention is to provide a process for preparing optically active tetrahydroquinoline derivatives which can be used for the treatment and/or prevention of diseases such as arteriosclerotic diseases, dyslipidemia and the like, and a process for preparing synthetic intermediates thereof.Specifically, (2R,4S)-2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-ylamine or a salt thereof is prepared with fewer steps without using an optical resolution, and the optically active tetrahydroquinoline derivatives are obtained from the amine compound.
公开/授权文献
- US20090292125A1 PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES 公开/授权日:2009-11-26
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