发明授权
US08084614B2 Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
有权
促性腺激素释放激素受体拮抗剂及其相关方法
- 专利标题： Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
- 专利标题（中）： 促性腺激素释放激素受体拮抗剂及其相关方法
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申请号： US12594809申请日： 2008-04-04
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公开(公告)号： US08084614B2公开(公告)日： 2011-12-27
- 发明人: Graham Beaton , Mi Chen , Timothy Richard Coon , Todd Ewing , Wanlong Jiang , Richard Lowe , Willy Moree , Nicole Smith , Warren Wade , Liren Zhao , Yun-fei Zhu , Martin Rowbottom , Neil Ashweek
- 申请人： Graham Beaton , Mi Chen , Timothy Richard Coon , Todd Ewing , Wanlong Jiang , Richard Lowe , Willy Moree , Nicole Smith , Warren Wade , Liren Zhao , Yun-fei Zhu , Martin Rowbottom , Neil Ashweek
- 申请人地址： US CA San Diego
- 专利权人： Neurocrine Biosciences, Inc.
- 当前专利权人： Neurocrine Biosciences, Inc.
- 当前专利权人地址： US CA San Diego
- 代理机构： Seed IP Law Group PLLC
- 国际申请： PCT/US2008/059438 WO 20080404
- 国际公布： WO2008/124610 WO 20081016
- 主分类号： C07D213/00
- IPC分类号： C07D213/00 ; C07D211/70 ; C07D233/00 ; A61K31/44
摘要：
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure, wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
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