发明授权
- 专利标题： Compositions, methods and kits relating to Her-2 cleavage
- 专利标题（中）： 与Her-2切割有关的组合物，方法和试剂盒
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申请号： US10817718申请日： 2004-04-02
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公开(公告)号： US08088737B2公开(公告)日： 2012-01-03
- 发明人: Steven M. Friedman , Peggy A. Scherle , Xiangdong Liu , Timothy C. Burn , Reid Huber , Phillip C. C. Liu , Gregory F. Hollis , Krishna Vaddi , Jordan S. Fridman
- 申请人： Steven M. Friedman , Peggy A. Scherle , Xiangdong Liu , Timothy C. Burn , Reid Huber , Phillip C. C. Liu , Gregory F. Hollis , Krishna Vaddi , Jordan S. Fridman
- 申请人地址： US DE Wilmington
- 专利权人： Incyte Corporation
- 当前专利权人： Incyte Corporation
- 当前专利权人地址： US DE Wilmington
- 代理机构： Fish & Richardson P.C.
- 主分类号： A01N61/00
- IPC分类号： A01N61/00 ; A61K31/00 ; A61K38/00 ; A61K39/395 ; G01N33/48
摘要：
The present invention relates to compositions, methods and kits based on the ADAM-mediated cleavage of Her-2. The present invention also relates to treatments for cancer, and in particular, breast cancer, by modulating the ADAM-mediated cleavage of Her-2. Further, the invention relates to compositions, methods and kits based on the surprising synergistic effect between inhibition of Her-2 cleavage by an ADAM and certain cytostatic (e.g., Herceptin) and cytotoxic (e.g., Taxol) compounds in, among other things, inhibiting tumor cell proliferation and inducing cell death. Additionally, the invention relates to novel variants of ADAM15, designated ADAM15 variant 1 and ADAM15 variant 2, now identified and isolated.
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