Invention Grant
- Patent Title: JAK-2 modulators and methods of use
- Patent Title (中): JAK-2调节剂和使用方法
-
Application No.: US12443103Application Date: 2007-09-28
-
Publication No.: US08088767B2Publication Date: 2012-01-03
- Inventor: Adam Antoni Galan , Jeff Chen , Hongwang Du , Timothy Forsyth , Tai Phat Huynh , Henry William Beecroft Johnson , Patrick Kearney , James W. Leahy , Matthew Sangyup Lee , Grace Mann , Brian Hugh Ridgway , Craig Stacy Takeuchi , Peiwen Zhou
- Applicant: Adam Antoni Galan , Jeff Chen , Hongwang Du , Timothy Forsyth , Tai Phat Huynh , Henry William Beecroft Johnson , Patrick Kearney , James W. Leahy , Matthew Sangyup Lee , Grace Mann , Brian Hugh Ridgway , Craig Stacy Takeuchi , Peiwen Zhou
- Applicant Address: US CA South San Francisco
- Assignee: Exelixis, Inc.
- Current Assignee: Exelixis, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- International Application: PCT/US2007/020982 WO 20070928
- International Announcement: WO2008/042282 WO 20080410
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/4439 ; A61K31/4184 ; C07D413/14 ; C07D401/14 ; C07D403/12
Abstract:
This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.
Public/Granted literature
- US20100136136A1 JAK-2 Modulators and Methods of Use Public/Granted day:2010-06-03
Information query
IPC分类:
