A method for motion search between video frames with multiple blocks is disclosed. The present invention provides an effective edge detection-prediction hexagon search algorithm (EDPHS algorithm). The method uses edge values and the distribution characteristics of motion vector and further overcomes the drawback of the conventional hexagon-based search algorithm (HEXBS algorithm). In this way, the present invention has less search points during searching. Through experiments, the present invention, without affecting the compressed video quality, reduces the number of search points by about 80%˜98% in comparison with the diamond search algorithm (DS algorithm) and reduces the number of search points by about 75%˜97% in comparison with the HEXBS algorithm. The advantages make the present invention suitable for the realizing real-time image compression.