发明授权
- 专利标题： Dry hemostatic compositions and methods for their preparation
- 专利标题（中）： 干燥止血组合物及其制备方法
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申请号： US12468316申请日： 2009-05-19
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公开(公告)号： US08092820B2公开(公告)日： 2012-01-10
- 发明人: Zhen Qian , A. Edward Osawa , Cary J. Reich
- 申请人： Zhen Qian , A. Edward Osawa , Cary J. Reich
- 申请人地址： US IL Deerfield CH Glattpark (Opfikon)
- 专利权人： Baxter International Inc.,Baxter Healthcare S.A.
- 当前专利权人： Baxter International Inc.,Baxter Healthcare S.A.
- 当前专利权人地址： US IL Deerfield CH Glattpark (Opfikon)
- 代理机构： Kilpatrick Townsend & Stockton LLP
- 主分类号： A61F13/00
- IPC分类号： A61F13/00 ; A61F2/00 ; A61K9/14 ; A61K9/50
摘要：
Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.