发明授权
- 专利标题: Method for using magnetic particles in droplet microfluidics
- 专利标题(中): 在微滴微流体中使用磁性颗粒的方法
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申请号: US12465935申请日: 2009-05-14
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公开(公告)号: US08093064B2公开(公告)日: 2012-01-10
- 发明人: Gaurav Jitendra Shah , Chang-Jin Kim
- 申请人: Gaurav Jitendra Shah , Chang-Jin Kim
- 申请人地址: US CA Oakland
- 专利权人: The Regents of the University of California
- 当前专利权人: The Regents of the University of California
- 当前专利权人地址: US CA Oakland
- 代理机构: Vista IP Law Group LLP
- 主分类号: G01N25/08
- IPC分类号: G01N25/08
摘要:
Methods of utilizing magnetic particles or beads (MBs) in droplet-based (or digital) microfluidics are disclosed. The methods may be used in enrichment or separation processes. A first method employs the droplet meniscus to assist in the magnetic collection and positioning of MBs during droplet microfluidic operations. The sweeping movement of the meniscus lifts the MBs off the solid surface and frees them from various surface forces acting on the MBs. A second method uses chemical additives to reduce the adhesion of MBs to surfaces. Both methods allow the MBs on a solid surface to be effectively moved by magnetic force. Droplets may be driven by various methods or techniques including, for example, electrowetting, electrostatic, electromechanical, electrophoretic, dielectrophoretic, electroosmotic, thermocapillary, surface acoustic, and pressure.