A method for control of humidity and auto-dispensing of pills in a pill box includes a box having multiple rooms defined therein which are shifted to be in alignment with an outlet. The method controls the humidity in each of the rooms and provides a control unit which controls a transmission unit to proceed a mechanical action to shift the rooms to be in alignment with the outlet according to a time setting signal so as to dispense at least one pill. The method includes a display unit to display time information and provides a reminder to take pills by way of audio and/or light.