Invention Grant
- Patent Title: Preparation of chiral amides and amines
- Patent Title (中): 手性酰胺和胺的制备
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Application No.: US12281819Application Date: 2007-03-30
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Publication No.: US08097760B2Publication Date: 2012-01-17
- Inventor: Hang Zhao , Stefan G. Koenig , Charles P. Vandenbossche , Surendra Singh , Harold Scott Wilkinson , Roger P. Bakale
- Applicant: Hang Zhao , Stefan G. Koenig , Charles P. Vandenbossche , Surendra Singh , Harold Scott Wilkinson , Roger P. Bakale
- Applicant Address: US MA Marlborough
- Assignee: Sunovion Pharmacuticals Inc.
- Current Assignee: Sunovion Pharmacuticals Inc.
- Current Assignee Address: US MA Marlborough
- International Application: PCT/US2007/065659 WO 20070330
- International Announcement: WO2007/115185 WO 20071011
- Main IPC: C07C321/00
- IPC: C07C321/00 ; C07C323/00 ; C07C381/00 ; C07C211/00

Abstract:
This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure.
Public/Granted literature
- US20090149549A1 PREPARATION OF CHIRAL AMIDES AND AMINES Public/Granted day:2009-06-11
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