发明授权
- 专利标题： Treatment methods using Dkk-1 antibodies
- 专利标题（中）： 使用Dkk-1抗体的治疗方法
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申请号： US12603303申请日： 2009-10-21
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公开(公告)号： US08101184B2公开(公告)日： 2012-01-24
- 发明人: Ji Li , Wenyan Shen , Hsieng Sen Lu , William Gleason Richards
- 申请人： Ji Li , Wenyan Shen , Hsieng Sen Lu , William Gleason Richards
- 申请人地址： US CA Thousand Oaks
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： US CA Thousand Oaks
- 代理商 Randolph N. Mohr
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/395
摘要：
The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.
公开/授权文献
- US20100040619A1 TREATMENT METHODS USING DKK-1 ANTIBODIES 公开/授权日：2010-02-18
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