发明授权
- 专利标题： Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer
- 专利标题（中）： 咪唑烷酰氨基嘧啶化合物治疗癌症
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申请号： US12516514申请日： 2007-12-11
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公开(公告)号： US08101628B2公开(公告)日： 2012-01-24
- 发明人: Harold Burns Brooks , Joyce Z. Crich , James Robert Henry , Hong-Yu Li , Melissa Kate Slater , Yan Wang
- 申请人： Harold Burns Brooks , Joyce Z. Crich , James Robert Henry , Hong-Yu Li , Melissa Kate Slater , Yan Wang
- 申请人地址： US IN Indianapolis
- 专利权人： Eli Lilly and Company
- 当前专利权人： Eli Lilly and Company
- 当前专利权人地址： US IN Indianapolis
- 代理商 Tina M. Tucker
- 国际申请： PCT/US2007/087044 WO 20071211
- 国际公布： WO2008/076704 WO 20080626
- 主分类号： C07D401/00
- IPC分类号： C07D401/00
摘要：
The present invention provides novel imidazolidinonyl aminopyrimidine compounds believed to have clinical use for treatment of cancer through inhibiting Plk1. wherein: R1 hydrogen, hydroxy, halo, methyl, C1-C2 alkoxy, amino, or methylamino; R2 is hydrogen, halo, or cyano; R3 is hydrogen or halo; R4 is hydrogen, halo, or methyl; provided that at least two of R1, R2, R3, and R4 are hydrogen; R5 is hydrogen, halo, or methyl; or a pharmaceutically acceptable salt thereof.
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