发明授权
- 专利标题： Process for synthesis of tritiated and deuterated thiorphan and acetorphan
- 专利标题（中）： 合成氚化和氘代噻吩和丙酮的方法
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申请号： US12316946申请日： 2008-12-17
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公开(公告)号： US08101665B2公开(公告)日： 2012-01-24
- 发明人: Mohammand R. Masjedizadeh , Shao-Yong Wu
- 申请人： Mohammand R. Masjedizadeh , Shao-Yong Wu
- 申请人地址： US CA Palo Alto
- 专利权人： Roche Palo Alto LLC
- 当前专利权人： Roche Palo Alto LLC
- 当前专利权人地址： US CA Palo Alto
- 代理商 Robert C. Hall
- 主分类号： A01N31/18
- IPC分类号： A01N31/18 ; A01N31/00 ; A61K31/165 ; A61K31/095 ; C07C321/00 ; C07C323/00 ; C07C318/00
摘要：
Methods for preparing tritium or deuterium labeled thiorphan comprising reacting a compound of formula j wherein m is from 1 to 5 and X is halo, with Z2 wherein Z is tritium or deuterium, in the presence of a catalyst, to form a compound of formula k wherein n is from 1 to 5, provided that n is less than or equal to m.
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