发明授权
US08106068B2 Compositions and methods for modulating c-kit and PDGFR receptors
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用于调节c-kit和PDGFR受体的组合物和方法
- 专利标题: Compositions and methods for modulating c-kit and PDGFR receptors
- 专利标题(中): 用于调节c-kit和PDGFR受体的组合物和方法
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申请号: US12629665申请日: 2009-12-02
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公开(公告)号: US08106068B2公开(公告)日: 2012-01-31
- 发明人: Zuosheng Liu , Jon Loren , Valentina Molteni , Juliet Nabakka
- 申请人: Zuosheng Liu , Jon Loren , Valentina Molteni , Juliet Nabakka
- 申请人地址: BM Hamilton
- 专利权人: IRM LLC
- 当前专利权人: IRM LLC
- 当前专利权人地址: BM Hamilton
- 代理机构: Genomics Institute of the Novartis Research Foundation
- 代理商 Emily Tongco Wu
- 主分类号: C07D471/04
- IPC分类号: C07D471/04 ; A61K31/4375 ; A61P29/00 ; A61P25/28 ; A61P25/04 ; A61P35/00 ; A61P9/12 ; A61P9/00
摘要:
The invention provides compounds of Formula (2), and pharmaceutical compositions thereof, wherein R1, R2, R3, R4 and L are as described herein; as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, KDR, c-raf or b-raf kinase, or mutant forms thereof.
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