发明授权
- 专利标题: Spiro-oxindole compounds and their uses as therapeutic agents
- 专利标题(中): 螺 - 羟吲哚化合物及其作为治疗剂的用途
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申请号: US12650196申请日: 2009-12-30
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公开(公告)号: US08106087B2公开(公告)日: 2012-01-31
- 发明人: Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
- 申请人: Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
- 申请人地址: CA Burnaby, B.C.
- 专利权人: Xenon Pharmaceuticals Inc.
- 当前专利权人: Xenon Pharmaceuticals Inc.
- 当前专利权人地址: CA Burnaby, B.C.
- 代理机构: Seed IP Law Group PLLC
- 主分类号: A61K31/407
- IPC分类号: A61K31/407 ; A61K31/5377
摘要:
This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
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