Invention Grant
- Patent Title: Spiro-oxindole compounds and their uses as therapeutic agents
- Patent Title (中): 螺 - 羟吲哚化合物及其作为治疗剂的用途
-
Application No.: US12650196Application Date: 2009-12-30
-
Publication No.: US08106087B2Publication Date: 2012-01-31
- Inventor: Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
- Applicant: Mikhail Chafeev , Nagasree Chakka , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Duanjie Hou , Tom Hsieh , Rajender Kamboj , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Jianyu Sun , Shaoyi Sun , Serguei Sviridov
- Applicant Address: CA Burnaby, B.C.
- Assignee: Xenon Pharmaceuticals Inc.
- Current Assignee: Xenon Pharmaceuticals Inc.
- Current Assignee Address: CA Burnaby, B.C.
- Agency: Seed IP Law Group PLLC
- Main IPC: A61K31/407
- IPC: A61K31/407 ; A61K31/5377

Abstract:
This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
Public/Granted literature
- US20100125072A1 SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS Public/Granted day:2010-05-20
Information query
IPC分类: