The invention provides in one aspect methods and apparatus for use with C-arm and other CT systems, e.g., with non-rigid geometries. In such systems, by way of example, calibration can be performed to determine the exact position of the x-ray source and the exact orientation of the detector where each projection measurement is made. Next, a weighting coefficient can be determined for the voxels in each plane of a reconstruction volume at every possible projection. Finally, the order in which to process the voxels during image reconstruction can be determined. Following an actual CT scan procedure in which scans are obtained of a volume to be constructed, a system according to these and related aspects of the invention can use an optimal, pre-calculated processing method, while utilizing offsets and weighting coefficients determined during calibration, for performing backprojection image reconstruction.