发明授权
- 专利标题： Diagnosis and treatment of chronic lymphocytic leukemia (CLL)
- 专利标题（中）： 慢性淋巴细胞性白血病（CLL）的诊断和治疗
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申请号： US12960955申请日： 2010-12-06
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公开(公告)号： US08114590B2公开(公告)日： 2012-02-14
- 发明人: Paul A. Insel , Lingzhi Zhang , Fionna Murray , Joan R. Kanter , Thomas Kipps , Laura Rassenti
- 申请人： Paul A. Insel , Lingzhi Zhang , Fionna Murray , Joan R. Kanter , Thomas Kipps , Laura Rassenti
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 代理机构： Sutherland Asbill & Brennan LLP
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C07H21/04
摘要：
The present invention provides diagnostic methods and kits for diagnosis of chronic lymphocytic leukemia (CLL) by determining expression levels of isoforms of cyclic nucleotide phosphodiesterases (PDEs) associated with CLL, particularly, PDE7B and/or PDE3B, and a ratio of mRNA expression of PDE7B to PDE3B. The present invention provides that CLL lymphocytes uniformly expressed high levels of PDE7B and low levels of PDE3B relative to those of normal lymphocytes. A method of treatment and a pharmaceutical composition for CLL comprising one or more therapeutic agents capable of modulating expression or activity levels of isoforms of PDEs associated with CLL, and/or reversing the ratio of PDE7B/PDE3B mRNA expression levels are also provided.
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