发明授权
US08114851B2 Method and medicament for inhibiting the expression of a given gene
有权
用于抑制给定基因表达的方法和药物
- 专利标题： Method and medicament for inhibiting the expression of a given gene
- 专利标题（中）： 用于抑制给定基因表达的方法和药物
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申请号： US11982434申请日： 2007-10-31
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公开(公告)号： US08114851B2公开(公告)日： 2012-02-14
- 发明人: Roland Kreutzer , Stefan Limmer
- 申请人： Roland Kreutzer , Stefan Limmer
- 申请人地址： US MA Cambridge
- 专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Fenwick & West LLP
- 优先权： DE19903713 19990130; DE19956568 19991124
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; C07H21/04
摘要：
The present invention relates to the specific inhibition of expression of a target gene in mammals using a short double stranded RNA. The dsRNA is less than 49 nucleotides in length and has a nucleotide sequence which is complementary to at least a part of the target gene. The dsRNAs of the present invention are useful for treating diseases, for example, cancer, viral diseases or neurodegenerative diseases.