发明授权
- 专利标题： Macrolide antibiotics and their use for medical purposes
- 专利标题（中）： 大环内酯抗生素及其用于医疗用途
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申请号： US12515695申请日： 2007-11-09
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公开(公告)号： US08114864B2公开(公告)日： 2012-02-14
- 发明人: Rolf Jansen , Brigitte Kunze , Herbert Irschik
- 申请人： Rolf Jansen , Brigitte Kunze , Herbert Irschik
- 申请人地址： DE Braunschweig
- 专利权人： Helmholtz-Zentrum Fuer Infektionsforschung
- 当前专利权人： Helmholtz-Zentrum Fuer Infektionsforschung
- 当前专利权人地址： DE Braunschweig
- 代理机构： Greer, Burns & Crain Ltd.
- 优先权： EP06125361 20061204
- 国际申请： PCT/EP2007/062107 WO 20071109
- 国际公布： WO2008/068127 WO 20080612
- 主分类号： A61K31/395
- IPC分类号： A61K31/395 ; C07D487/04
摘要：
The invention provides novel Thuggacin-Type macrolide compounds which form rearrangement products forming a lacton bond to different carbon atoms. The novel compounds can be produced by fermentation of Sorangium cellulosum and Chondromyces crocatus and can be isolated by adsorption and chromoatograhic processing steps. The compounds are found to have antibiotic activity. The invention also relates to Thuggacin A, Thuggacin B, Thuggacin C, 13-Methyl-Thuggacin A, Thuggacin CMC-A, Thuggacin CMC-B and Thuggacin CMC-C AS Antimycobacterial Agents.
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