Invention Grant
US08114871B2 3-amido-pyrrolo[3,4-C]pyrazole-5(1H,4H,6H) carbaldehyde derivatives
有权
3-氨基 - 吡咯并[3,4-C]吡唑-5（1H，4H，6H）甲醛衍生物
![3-amido-pyrrolo[3,4-C]pyrazole-5(1H,4H,6H) carbaldehyde derivatives](/docs/US/2012-02-14/US08114871B2/abs.jpg.600x600.jpg)
- Patent Title: 3-amido-pyrrolo[3,4-C]pyrazole-5(1H,4H,6H) carbaldehyde derivatives
- Patent Title (中): 3-氨基 - 吡咯并[3,4-C]吡唑-5（1H，4H，6H）甲醛衍生物
-
Application No.: US12532051Application Date: 2008-04-10
-
Publication No.: US08114871B2Publication Date: 2012-02-14
- Inventor: Iriny Botrous , Yufeng Hong , Hui Li , Kevin Kun-Chin Liu , Seiji Nukui , Min Teng , Eileen Valenzuela Tompkins , Chunfeng Yin
- Applicant: Iriny Botrous , Yufeng Hong , Hui Li , Kevin Kun-Chin Liu , Seiji Nukui , Min Teng , Eileen Valenzuela Tompkins , Chunfeng Yin
- Applicant Address: US NY New York US CT Groton
- Assignee: Pfizer Inc.,Pfizer Products Inc.
- Current Assignee: Pfizer Inc.,Pfizer Products Inc.
- Current Assignee Address: US NY New York US CT Groton
- Agency: Wilson, Sonsini, Goodrich & Rosati
- International Application: PCT/IB2008/000862 WO 20080410
- International Announcement: WO2008/125945 WO 20081023
- Main IPC: A61K31/535
- IPC: A61K31/535 ; A61K31/495 ; A61K31/497 ; A61K31/4965 ; C07D413/14 ; C07D237/00 ; C07D239/00 ; C07D403/14 ; C07D241/36 ; C07D401/14
![3-amido-pyrrolo[3,4-C]pyrazole-5(1H,4H,6H) carbaldehyde derivatives](/abs-image/US/2012/02/14/US08114871B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to compounds and pharmaceutically acceptable salts of Formula (I): wherein X, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined above. The invention further relates to pharmaceutical compositions comprising the compounds and pharmaceutically acceptable salts and to methods of treating diabetes mellitus and its complications (including in particular diabetic retinopathy, nephropathy or neuropathy), cancer, ischemia, inflammation, central nervous system disorders, cardiovascular disease, Alzheimer's disease and dermatological disease pression, viral diseases, inflammatory disorders, or diseases in which the liver is a target organ.
Public/Granted literature
- US20100249128A1 NOVEL 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H,4H,6H) CARBALDEHYDE DERIVATIVES Public/Granted day:2010-09-30
Information query
