发明授权
US08114871B2 3-amido-pyrrolo[3,4-C]pyrazole-5(1H,4H,6H) carbaldehyde derivatives
有权
3-氨基 - 吡咯并[3,4-C]吡唑-5（1H，4H，6H）甲醛衍生物
![3-amido-pyrrolo[3,4-C]pyrazole-5(1H,4H,6H) carbaldehyde derivatives](/docs/US/2012-02-14/US08114871B2/abs.jpg.600x600.jpg)
- 专利标题： 3-amido-pyrrolo[3,4-C]pyrazole-5(1H,4H,6H) carbaldehyde derivatives
- 专利标题（中）： 3-氨基 - 吡咯并[3,4-C]吡唑-5（1H，4H，6H）甲醛衍生物
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申请号： US12532051申请日： 2008-04-10
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公开(公告)号： US08114871B2公开(公告)日： 2012-02-14
- 发明人: Iriny Botrous , Yufeng Hong , Hui Li , Kevin Kun-Chin Liu , Seiji Nukui , Min Teng , Eileen Valenzuela Tompkins , Chunfeng Yin
- 申请人： Iriny Botrous , Yufeng Hong , Hui Li , Kevin Kun-Chin Liu , Seiji Nukui , Min Teng , Eileen Valenzuela Tompkins , Chunfeng Yin
- 申请人地址： US NY New York US CT Groton
- 专利权人： Pfizer Inc.,Pfizer Products Inc.
- 当前专利权人： Pfizer Inc.,Pfizer Products Inc.
- 当前专利权人地址： US NY New York US CT Groton
- 代理机构： Wilson, Sonsini, Goodrich & Rosati
- 国际申请： PCT/IB2008/000862 WO 20080410
- 国际公布： WO2008/125945 WO 20081023
- 主分类号： A61K31/535
- IPC分类号： A61K31/535 ; A61K31/495 ; A61K31/497 ; A61K31/4965 ; C07D413/14 ; C07D237/00 ; C07D239/00 ; C07D403/14 ; C07D241/36 ; C07D401/14
![3-amido-pyrrolo[3,4-C]pyrazole-5(1H,4H,6H) carbaldehyde derivatives](/abs-image/US/2012/02/14/US08114871B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to compounds and pharmaceutically acceptable salts of Formula (I): wherein X, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined above. The invention further relates to pharmaceutical compositions comprising the compounds and pharmaceutically acceptable salts and to methods of treating diabetes mellitus and its complications (including in particular diabetic retinopathy, nephropathy or neuropathy), cancer, ischemia, inflammation, central nervous system disorders, cardiovascular disease, Alzheimer's disease and dermatological disease pression, viral diseases, inflammatory disorders, or diseases in which the liver is a target organ.