Invention Grant
US08114874B2 Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors
有权
取代的炔属咪唑并[1,2-B]哒嗪化合物作为激酶抑制剂
![Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors](/docs/US/2012-02-14/US08114874B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors
- Patent Title (中): 取代的炔属咪唑并[1,2-B]哒嗪化合物作为激酶抑制剂
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Application No.: US11644849Application Date: 2006-12-22
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Publication No.: US08114874B2Publication Date: 2012-02-14
- Inventor: Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antionette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
- Applicant: Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antionette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
- Applicant Address: US MA Cambridge
- Assignee: ARIAD Pharmaceuticals, Inc.
- Current Assignee: ARIAD Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agent David L. Berstein; Christopher J. Verni
- Main IPC: A61K31/495
- IPC: A61K31/495
![Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors](/abs-image/US/2012/02/14/US08114874B2/abs.jpg.150x150.jpg)
Abstract:
This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use. In particular, the compounds include embodiments in which Ring T is an imidazo[1,2-b]pyridazine ring system, Rings A and B are each aryl and L1 is —C(O)NR1— or —NR1C(O)—. Uses for the compounds and for compositions containing them include treatment of cancer and other diseases mediated by protein kinases.
Public/Granted literature
- US20070191376A1 Bicyclic heteroaryl compounds Public/Granted day:2007-08-16
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