Invention Grant
US08114895B2 Use of bipyridine compound ‘Caerulomycin A’ derivatives and analogs thereof as immunosuppressive agents
有权
联吡啶化合物“Caerulomycin A”衍生物及其类似物作为免疫抑制剂
- Patent Title: Use of bipyridine compound ‘Caerulomycin A’ derivatives and analogs thereof as immunosuppressive agents
- Patent Title (中): 联吡啶化合物“Caerulomycin A”衍生物及其类似物作为免疫抑制剂
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Application No.: US11519200Application Date: 2006-09-12
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Publication No.: US08114895B2Publication Date: 2012-02-14
- Inventor: Arvind Kumar Singla , Javed Naim Agrewala , Rakesh Mulraj Vohra , Ravinder Singh Jolly
- Applicant: Arvind Kumar Singla , Javed Naim Agrewala , Rakesh Mulraj Vohra , Ravinder Singh Jolly
- Applicant Address: IN New Delhi
- Assignee: Council of Science and Industrial Research
- Current Assignee: Council of Science and Industrial Research
- Current Assignee Address: IN New Delhi
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: IN2465/DEL/2005 20050912
- Main IPC: A61K31/44
- IPC: A61K31/44
Abstract:
The present invention relates to an isolated bioactive molecule Caerulomycin A, derivatives and analogs thereof as effective immunosuppressive agents. The immunosuppressive property of the compound is targeted in particular against the lymphocytes, CD4+ T cells, CD8+ T cells and B cells and in the production of IL-4 and IFN-γ and antibodies. The compound operates through a mechanism by downregulating the expression of activation marker CD28 and upregulating the immunosuppressive marker CTLA-4. Caerulomycin A has previously been isolated from Streptomyces caeruleus and found to have useful antifungal activity. Prior to the present invention however, this compound had not been determined to have immunomodulatory activity.
Public/Granted literature
- US20070078167A1 Use of bipyridine compound 'Caerulomycin A' derivatives and analogs thereof as immunosuppressive agents Public/Granted day:2007-04-05
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