发明授权
- 专利标题: C-phenyl 1-thioglucitol compound
- 专利标题(中): C-苯基1-硫代葡萄糖醇化合物
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申请号: US12305157申请日: 2007-06-28
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公开(公告)号: US08115017B2公开(公告)日: 2012-02-14
- 发明人: Hiroyuki Kakinuma , Takahiro Oi , Yohei Kobashi , Yuko Hashimoto , Hitomi Takahashi
- 申请人: Hiroyuki Kakinuma , Takahiro Oi , Yohei Kobashi , Yuko Hashimoto , Hitomi Takahashi
- 申请人地址: JP Tokyo
- 专利权人: Taisho Pharmaceutical Co., Ltd
- 当前专利权人: Taisho Pharmaceutical Co., Ltd
- 当前专利权人地址: JP Tokyo
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2006-179971 20060629
- 国际申请: PCT/JP2007/063031 WO 20070628
- 国际公布: WO2008/001864 WO 20080103
- 主分类号: C70D335/02
- IPC分类号: C70D335/02
摘要:
C-phenyl 1-thioglucitol compounds of the following formula (I) or pharmaceutically acceptable salts thereof or hydrates thereof: [wherein X represents a hydrogen atom or a C1-6 alkyl group, Y represents a C1-6 alkylene group or —O—(CH2)n- (wherein n represents an integer of 1 to 5), and Z represents —CONHRA or —NHCONHRB (provided that when Z represents —NHCONHRB, n is not 1), wherein RA represents a C1-6 alkyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxyl group and —CONH2, and RB represents a hydrogen atom or a C1-6 alkyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxyl group and —CONH2] are useful as prophylactic or therapeutic agents for diabetes, because of their suppressive effect on sugar (e.g., glucose) absorption through inhibition of SGLT1 activity, or alternatively, because of their suppressive effect on sugar (e.g., glucose) absorption and excretory effect on urinary sugars through inhibition of both SGLT1 and SGLT2 activities.
公开/授权文献
- US20100004465A1 C-PHENYL 1-THIOGLUCITOL COMPOUND 公开/授权日:2010-01-07
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