发明授权
- 专利标题: Shortened synthesis using paraformaldehyde or trioxane
- 专利标题(中): 使用多聚甲醛或三恶烷缩短合成
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申请号: US12304008申请日: 2007-06-05
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公开(公告)号: US08115028B2公开(公告)日: 2012-02-14
- 发明人: Seth C. Ennis , Cornelia Fuchs , Ralf Kanzler , Dean A. Johnson
- 申请人: Seth C. Ennis , Cornelia Fuchs , Ralf Kanzler , Dean A. Johnson
- 代理机构: Kenyon & Kenyon LLP
- 优先权: EP06012053 20060612; IES2006/0435 20060612
- 国际申请: PCT/EP2007/004976 WO 20070605
- 国际公布: WO2007/144091 WO 20071221
- 主分类号: C07C69/035
- IPC分类号: C07C69/035
摘要:
The present disclosure relates to a process for the preparation of a compound of formula (I) wherein R is hydrogen, a formyl group, a straight, branched or cyclic C1-C6 alkylcarbonyl group or a phenylcarbonyl group, or a salt thereof, characterized by the steps of reacting a compound of formula (II) with a mixture of Grignard initiator and Mg in a solvent to form a Grignard reagent, reacting the Grignard reagent with paraformaldehyde or trioxane to obtain a compound of formula (III) and then further reacting the compound of formula (III) in a known manner to obtain a compound of formula (I) and optionally salt formation.
公开/授权文献
- US20100292499A1 SHORTENED SYNTHESIS USING PARAFORMALDEHYDE OR TRIOXANE 公开/授权日:2010-11-18
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