A method and system for calibrating an initial driving signal for driving an optical pick-up head of an optical disk drive is provided. On one embodiment, said optical disk drive is utilized for reading or writing data on an optical disk, the optical disk includes a plurality of auto power control areas (APC areas) and a plurality of data areas, and the APC areas and the data areas are interleaved in between. In at least one of the APC areas that before the data areas for a normal data writing, an initial driving signal is used for the normal data writing to drive the optical pick-up head to emit laserbeam. A detected level of the laserbeam is then obtained. An update initial driving signal is then calibrated according to the detected level and a target level.