An endovascular graft of the present invention embodies a graft system utilizing the textile fabric of the prosthesis for drug storage and delivery. These drug-eluting devices involve treating the textile fabric with therapeutic agents to provide a method of delivery to both the outer surface of the graft and the inner surface of the graft. An endovascular graft system having a fuzz texturing on the outer periphery of the graft where the texturing includes a therapeutic agent coating applied to the texturing material is also contemplated. An expandable attachment frame further includes drug storage and delivery capabilities in the cavities formed in the V-hooks and apices. Therapeutic agents can also included in the radiopaque coating or loading to serve as a reservoir for controlled drug delivery.