Invention Grant
- Patent Title: Human cytomegalovirus neutralizing antibodies and use thereof
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Application No.: US12503822Application Date: 2009-07-15
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Publication No.: US08124093B2Publication Date: 2012-02-28
- Inventor: Antonio Lanzavecchia , Annalisa Macagno
- Applicant: Antonio Lanzavecchia , Annalisa Macagno
- Applicant Address: CH Bellinzona
- Assignee: Institute for Research in Biomedicine
- Current Assignee: Institute for Research in Biomedicine
- Current Assignee Address: CH Bellinzona
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Jeanne M. DiGiorgio, Esq.
- Main IPC: A61K39/42
- IPC: A61K39/42 ; A61K39/395 ; A61K39/00 ; A61K39/25 ; C12P21/08 ; C07K15/00
Abstract:
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.
Public/Granted literature
- US20100092481A1 HUMAN CYTOMEGALOVIRUS NEUTRALISING ANTIBODIES AND USE THEREOF Public/Granted day:2010-04-15
Information query
