Invention Grant
US08124392B2 Crystal structure of Aurora-2 protein and binding pockets thereof
失效
Aurora-2蛋白的晶体结构及其结合口袋
- Patent Title: Crystal structure of Aurora-2 protein and binding pockets thereof
- Patent Title (中): Aurora-2蛋白的晶体结构及其结合口袋
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Application No.: US12890826Application Date: 2010-09-27
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Publication No.: US08124392B2Publication Date: 2012-02-28
- Inventor: Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce T. Coll , Suzanne Renwick , Peter Weber
- Applicant: Graham Cheetham , Ronald Knegtel , Lovorka Swenson , Joyce T. Coll , Suzanne Renwick , Peter Weber
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Cambridge
- Agency: Ropes & Gray LLP
- Agent James F. Haley, Jr.; Raymond M. Doss
- Main IPC: C12N9/12
- IPC: C12N9/12 ; G01N31/00
Abstract:
The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.
Public/Granted literature
- US20110104782A1 CRYSTAL STRUCTURE OF AURORA-2 PROTEIN AND BINDING POCKETS THEREOF Public/Granted day:2011-05-05
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