发明授权
US08124639B2 Bicyclic [3.1.0] heteroaryl amides as type 1 glycine transport inhibitors
有权
双环[3.1.0]杂芳基酰胺作为1型甘氨酸转运抑制剂
![Bicyclic [3.1.0] heteroaryl amides as type 1 glycine transport inhibitors](/docs/US/2012-02-28/US08124639B2/abs.jpg.600x600.jpg)
- 专利标题： Bicyclic [3.1.0] heteroaryl amides as type 1 glycine transport inhibitors
- 专利标题（中）： 双环[3.1.0]杂芳基酰胺作为1型甘氨酸转运抑制剂
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申请号： US12870928申请日： 2010-08-30
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公开(公告)号： US08124639B2公开(公告)日： 2012-02-28
- 发明人: Stanton F. McHardy , John A. Lowe, III
- 申请人： Stanton F. McHardy , John A. Lowe, III
- 申请人地址： US NY New York
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 当前专利权人地址： US NY New York
- 代理商 Gregg C. Benson; Ian Lodovice
- 主分类号： A61K31/403
- IPC分类号： A61K31/403 ; A61K31/4178 ; C07D403/12 ; C07D209/52
![Bicyclic [3.1.0] heteroaryl amides as type 1 glycine transport inhibitors](/abs-image/US/2012/02/28/US08124639B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to a series of substituted bicyclic[3.1.0]heteroaryl amides of the Formula I, wherein A, Q, X, Y, Z and R1-R5 groups are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use for the enhancement of cognition and the treatment of the positive and negative symptoms of schizophrenia and other psychoses in mammals, including humans.