发明授权
- 专利标题： Stereoselective process and crystalline forms of a camptothecin
- 专利标题（中）： 喜树碱的立体选择性方法和结晶形式
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申请号： US12857743申请日： 2010-08-17
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公开(公告)号： US08124769B2公开(公告)日： 2012-02-28
- 发明人: Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
- 申请人： Paolo Carminati , Maria Ornella Tinti , Mauro Marzi , Fabrizio Giorgi , Walter Cabri , Marco Alpegiani , Domenico Vergani , Paolo Ghetti
- 申请人地址： IT Rome
- 专利权人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人地址： IT Rome
- 代理机构： Lucas & Mercanti, LLP
- 优先权： EP04030246 20041221
- 主分类号： C07D471/00
- IPC分类号： C07D471/00 ; A01N43/42
摘要：
A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
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