Described is a technology by which a computer pointing device (generally a mouse but alternatively a game controller or remote control device) may be worn on the hand and operated without needing to contact a mousing surface. Gyroscopic-based sensors convert the wearer's hand and wrist movements to signals which are sent to a host computing device such as a conventional personal computer, a gaming console, an electronic appliance, and so forth. The data received from the pointing device may be used to move a cursor or the like, and other received data may correspond to left and right mouse clicks, scrolling operations, and so forth. A user-controlled enable switch/sensor selectively activates or deactivates the pointing device so that only intended movements result in data transmission. Gestures may also be sensed and used to trigger defined functions.