The pneumatic tire for two-wheeled vehicles including a plurality of tread rubbers constituting a tread wherein a region occupying 15 to 35% in the center of a stretched tread width, which is obtained by stretching the tread with respect to a tire equatorial plane as the center, is defined as a tread central section; the remaining regions at both ends are defined as tread side sections; regions in the respective tread side sections each occupying 4 to 13% from the corresponding tread end toward the center of the stretched tread width are defined as side-section shoulder-end regions; and the remaining regions of the respective tread side sections are defined as side-section near-center regions, a modulus of the tread rubbers for the side-section shoulder-end regions at 100% elongation is smaller than a modulus of the tread rubbers for the side-section near-center regions at 100% elongation, at least at a tread surface.