发明授权
- 专利标题： Method for treatment or prevention of disease associated with functional disorder of regulatory T cell
- 专利标题（中）： 治疗或预防与调节性T细胞功能紊乱相关的疾病的方法
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申请号： US12084907申请日： 2006-11-14
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公开(公告)号： US08128934B2公开(公告)日： 2012-03-06
- 发明人: Akio Suzumura , Jinyan Wang , Takashi Matsui , Sadatoshi Sakuma , Shin Miyakawa , Masatoshi Fujiwara , Yoshikazu Nakamura
- 申请人： Akio Suzumura , Jinyan Wang , Takashi Matsui , Sadatoshi Sakuma , Shin Miyakawa , Masatoshi Fujiwara , Yoshikazu Nakamura
- 申请人地址： JP Tokyo AU Sydney
- 专利权人： Ribomic, Inc.,Cellmid Limited
- 当前专利权人： Ribomic, Inc.,Cellmid Limited
- 当前专利权人地址： JP Tokyo AU Sydney
- 代理机构： Wenderoth, Lind & Ponack, LLP
- 优先权： JP2005-329418 20051114
- 国际申请： PCT/JP2006/322659 WO 20061114
- 国际公布： WO2007/055378 WO 20070518
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/22
摘要：
The inventors examined the role of MK in experimental autoimmune encephalomyelitis, which is a human model for multiple sclerosis. As a result, they discovered that MK has the effect of inhibiting regulatory T cells, and that the autoimmune mechanism induced by type 1 helper T cells can be suppressed by inhibiting MK expression or its activity, thereby increasing the number of regulatory T cells. Furthermore, it was found that diseases associated with the functional disorder of regulatory T cells can be treated with the administration of an inhibitor that inhibits MK expression or activity.
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