发明授权
US08128944B2 RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles 有权
RNA序列基序在定义的核苷酸间键的背景下诱导特异性免疫调节谱

  • 专利标题: RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles
  • 专利标题(中): RNA序列基序在定义的核苷酸间键的背景下诱导特异性免疫调节谱
  • 申请号: US12670697
    申请日: 2008-08-08
  • 公开(公告)号: US08128944B2
    公开(公告)日: 2012-03-06
  • 发明人: Marion JurkJorg Vollmer
  • 申请人: Marion JurkJorg Vollmer
  • 申请人地址: DE Dusseldorf
  • 专利权人: Coley Pharmaceutical GmbH
  • 当前专利权人: Coley Pharmaceutical GmbH
  • 当前专利权人地址: DE Dusseldorf
  • 代理商 Paul M. Misiak
  • 国际申请: PCT/IB2008/002104 WO 20080808
  • 国际公布: WO2009/022216 WO 20090219
  • 主分类号: A61K47/00
  • IPC分类号: A61K47/00 A61K31/00 C07H21/04
RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles
摘要:
Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
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