发明授权
US08128944B2 RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles
有权
RNA序列基序在定义的核苷酸间键的背景下诱导特异性免疫调节谱
- 专利标题: RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles
- 专利标题(中): RNA序列基序在定义的核苷酸间键的背景下诱导特异性免疫调节谱
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申请号: US12670697申请日: 2008-08-08
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公开(公告)号: US08128944B2公开(公告)日: 2012-03-06
- 发明人: Marion Jurk , Jorg Vollmer
- 申请人: Marion Jurk , Jorg Vollmer
- 申请人地址: DE Dusseldorf
- 专利权人: Coley Pharmaceutical GmbH
- 当前专利权人: Coley Pharmaceutical GmbH
- 当前专利权人地址: DE Dusseldorf
- 代理商 Paul M. Misiak
- 国际申请: PCT/IB2008/002104 WO 20080808
- 国际公布: WO2009/022216 WO 20090219
- 主分类号: A61K47/00
- IPC分类号: A61K47/00 ; A61K31/00 ; C07H21/04
摘要:
Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
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