发明授权
US08128945B2 Drug delivery system targeting to estrogen receptor over-expressed cells
有权
药物递送系统靶向雌激素受体过表达细胞
- 专利标题： Drug delivery system targeting to estrogen receptor over-expressed cells
- 专利标题（中）： 药物递送系统靶向雌激素受体过表达细胞
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申请号： US12886083申请日： 2010-09-20
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公开(公告)号： US08128945B2公开(公告)日： 2012-03-06
- 发明人: Shyh-Dar Li , Ae-June Wang , Chung-Kung Lai
- 申请人： Shyh-Dar Li , Ae-June Wang , Chung-Kung Lai
- 申请人地址： TW Hsinchu
- 专利权人： Industrial Technology Research Institute
- 当前专利权人： Industrial Technology Research Institute
- 当前专利权人地址： TW Hsinchu
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 优先权： TW91138150A 20021231
- 主分类号： A61K9/51
- IPC分类号： A61K9/51
摘要：
A vector for targeted delivery of drugs into estrogen receptors over-expressed cells is disclosed. The vector of the present invention is mainly about an active targeting delivery carrier which consists of a plurality of nanoparticles including: (i) a plurality of targeted moiety conjugated to the outer surface of the nanoparticles, the moiety being capable of binding with the estrogen receptor of a target cell, and (ii) bioactive agents encapsulated in the nanoparticles or forming complex with the nanoparticles. The targeted moiety of the present invention can also be conjugated to parent drugs for prodrug design.
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