Invention Grant
US08129377B2 6-(pyridinyl)-4-pyrimidone derivates as tau protein kinase 1 inhibitors
有权
6-（吡啶基）-4-嘧啶酮衍生物作为tau蛋白激酶1抑制剂
- Patent Title: 6-(pyridinyl)-4-pyrimidone derivates as tau protein kinase 1 inhibitors
- Patent Title (中): 6-（吡啶基）-4-嘧啶酮衍生物作为tau蛋白激酶1抑制剂
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Application No.: US11576062Application Date: 2005-09-29
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Publication No.: US08129377B2Publication Date: 2012-03-06
- Inventor: Kazutoshi Watanabe , Kenji Fukunaga , Toshiyuki Kohara , Fumiaki Uehara , Shinsuke Hiki , Satoshi Yokoshima
- Applicant: Kazutoshi Watanabe , Kenji Fukunaga , Toshiyuki Kohara , Fumiaki Uehara , Shinsuke Hiki , Satoshi Yokoshima
- Applicant Address: JP Osaka FR Paris
- Assignee: Mitsubishi Tanabe Pharma Corporation,Sanofi-Aventis
- Current Assignee: Mitsubishi Tanabe Pharma Corporation,Sanofi-Aventis
- Current Assignee Address: JP Osaka FR Paris
- Agency: Greenblum & Bernstein, PLC
- Priority: JP2004-313115 20040929
- International Application: PCT/JP2005/018497 WO 20050929
- International Announcement: WO2006/036015 WO 20060406
- Main IPC: A61K31/535
- IPC: A61K31/535 ; A61K31/505 ; A01N43/54 ; C07D413/00
Abstract:
A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein R1 represents a C1-C12 alkyl; R2 represents a hydrogen atom or the like; R3 represents a halogen or the like; q represents an integer of 1 to 7; R4 represents a halogen or the like; p represents 0 or an integer of 1 to 5; R5 represents a C6-C10 aryl, a heterocycle or the like; and X represents oxygen, NH, or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).
Public/Granted literature
- US20090239864A1 6- (PYRIDINYL) -4-PYRIMIDONE DERIVATES AS TAU PROTEIN KINASE 1 INHIBITORS Public/Granted day:2009-09-24
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