发明授权
US08129385B2 Substituted 5-hydroxy-3,4,6,9,9a, 10-hexanhydro-2h-1-oxa04a,8a-diaza-anthracene-6,10-dioness
有权
取代的5-羟基-3,4,6,9,9a，10-六氢-2h-1-氧杂-4a，8a-二氮杂 - 蒽-6,10-二酮
- 专利标题： Substituted 5-hydroxy-3,4,6,9,9a, 10-hexanhydro-2h-1-oxa04a,8a-diaza-anthracene-6,10-dioness
- 专利标题（中）： 取代的5-羟基-3,4,6,9,9a，10-六氢-2h-1-氧杂-4a，8a-二氮杂 - 蒽-6,10-二酮
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申请号： US11919386申请日： 2006-04-28
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公开(公告)号： US08129385B2公开(公告)日： 2012-03-06
- 发明人: Brian Alvin Johns , Takashi Kawasuji , Teruhiko Taishi , Yoshiyuki Taoda
- 申请人： Brian Alvin Johns , Takashi Kawasuji , Teruhiko Taishi , Yoshiyuki Taoda
- 申请人地址： JP Osaka US PA Philadelphia
- 专利权人： Shionogi & Co., Ltd.,GlaxoSmithKline LLC
- 当前专利权人： Shionogi & Co., Ltd.,GlaxoSmithKline LLC
- 当前专利权人地址： JP Osaka US PA Philadelphia
- 代理机构： Wenderoth, Lind & Ponack, L.L.P.
- 优先权： JP2005-131161 20050428; JP2005-312076 20051027
- 国际申请： PCT/US2006/016604 WO 20060428
- 国际公布： WO2006/116764 WO 20061102
- 主分类号： A61K31/495
- IPC分类号： A61K31/495
摘要：
The present invention is directed to a class of substituted 5-hydroxy-3,4,6,9,9a,10-hexahydro-2H-1-oxa-4a,8a-diaza-anthracene-6,10-diones useful as anti-HIV agents. The compounds have the formula: Z═O; R20, R21, R22, R23, R24 and R25 independently are hydrogen, C1-C8 alkyl, (C6-C14)aryl-(C1-C8)alkyl, C6-C14 aryl, or alkoxy; the stereochemistry of an asymmetric carbon represented by * shows R- or S-configuration, or a mixture thereof; RX is hydrogen; R14 is hydrogen or optionally substituted lower alkyl; R3 is hydrogen; R1 is hydrogen or lower alkyl; R is halogen; and m is 1, 2 or 3; or a pharmaceutically acceptable salt thereof.
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