发明授权
US08133901B2 3-heteroaryl (amino or amido)-1-(biphenyl or phenylthiazolyl) carbonylpiperidine derivatives as orexin receptor inhibitors
失效
(氨基或酰氨基)-1-(联苯基或苯基噻唑基)羰基哌啶衍生物作为食欲素受体抑制剂
- 专利标题: 3-heteroaryl (amino or amido)-1-(biphenyl or phenylthiazolyl) carbonylpiperidine derivatives as orexin receptor inhibitors
- 专利标题(中): (氨基或酰氨基)-1-(联苯基或苯基噻唑基)羰基哌啶衍生物作为食欲素受体抑制剂
-
申请号: US12517010申请日: 2007-11-29
-
公开(公告)号: US08133901B2公开(公告)日: 2012-03-13
- 发明人: Hamed Aissaoui , Christoph Boss , Markus Gude , Ralf Koberstein , Thierry Sifferlen
- 申请人: Hamed Aissaoui , Christoph Boss , Markus Gude , Ralf Koberstein , Thierry Sifferlen
- 申请人地址: CH Allschwil
- 专利权人: Actelion Pharmaceuticals Ltd.
- 当前专利权人: Actelion Pharmaceuticals Ltd.
- 当前专利权人地址: CH Allschwil
- 代理机构: Hoxie & Associates LLC
- 代理商 Brittany La
- 优先权: WOPCTIB2006/054549 20061201
- 国际申请: PCT/IB2007/054851 WO 20071129
- 国际公布: WO2008/065626 WO 20080605
- 主分类号: C07D401/12
- IPC分类号: C07D401/12 ; C07D417/14 ; C07D513/04 ; A61K31/506
摘要:
The invention relates to piperidine compounds of formula (I): wherein X—R1 represents —N(H)-pyrimidinyl, wherein said pyrimidinyl is unsubstituted or mono-substituted wherein the substituent is selected from (C1-4)alkyl or halogen, or X—R1 represents —NH—C(O)-heterocyclyl, wherein the heterocyclyl is selected from benzofuranyl and imidazo[2,1-b]-thiazolyl, wherein said heterocyclyl is unsubstituted or independently mono-, di- or tri-substituted wherein the substituents are independently selected from (C1-4)alkyl; A represents a phenyl- or thiazolyl-group, wherein the phenyl or thiazolyl is unsubstituted or mono-substituted with (C1-4)alkyl; B represents a phenyl-group, wherein the phenyl is unsubstituted or mono-, or di- substituted, wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, trifluoromethyl, cyano and halogen; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.
公开/授权文献
信息查询