发明授权
US08133915B2 Interleukin-1 and tumor necrosis factor-α modulators; syntheses of such modulators and methods of using such modulators
有权
白介素-1和肿瘤坏死因子-α调节剂; 这种调节剂的合成和使用这种调节剂的方法
- 专利标题： Interleukin-1 and tumor necrosis factor-α modulators; syntheses of such modulators and methods of using such modulators
- 专利标题（中）： 白介素-1和肿瘤坏死因子-α调节剂; 这种调节剂的合成和使用这种调节剂的方法
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申请号： US13007573申请日： 2011-01-14
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公开(公告)号： US08133915B2公开(公告)日： 2012-03-13
- 发明人: Michael A. Palladino , Emmanuel A. Theodorakis , Venkat Rami Reddy Macherla , Ta-Hsiang Chao , Young-Ger Suh
- 申请人： Michael A. Palladino , Emmanuel A. Theodorakis , Venkat Rami Reddy Macherla , Ta-Hsiang Chao , Young-Ger Suh
- 申请人地址： US CA San Diego US CA Oakland
- 专利权人： Nereus Pharmaceuticals, Inc.,The Regents of the University of California
- 当前专利权人： Nereus Pharmaceuticals, Inc.,The Regents of the University of California
- 当前专利权人地址： US CA San Diego US CA Oakland
- 代理机构： Knobbe Martens Olson & Bear LLP
- 主分类号： A61K31/165
- IPC分类号： A61K31/165
摘要：
Described herein are chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. Also described are methods of synthesizing natural products and novel, structurally-related chemical compounds. More particularly, disclosed are new analogs of and processes for the preparation of compounds and pharmaceutical compositions thereof useful in the treatment of, for example, inflammation, cancer, multiple myeloma, cachexia, cardiovascular disease, anti-infectious, diabetes, otitis media, sinusitis and transplant rejection.
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