发明授权
- 专利标题： Fused bicyclic pyrimidine compounds as aurora kinase inhibitors
- 专利标题（中）： 稠合双环嘧啶化合物作为极光激酶抑制剂
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申请号： US12428044申请日： 2009-04-22
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公开(公告)号： US08138194B2公开(公告)日： 2012-03-20
- 发明人: Hsing-Pang Hsieh , Selvaraj Mohane Coumar , Tsu-An Hsu , Su-Ying Wu , Yu-Sheng Chao
- 申请人： Hsing-Pang Hsieh , Selvaraj Mohane Coumar , Tsu-An Hsu , Su-Ying Wu , Yu-Sheng Chao
- 申请人地址： TW Miaoli County
- 专利权人： National Health Research Institutes
- 当前专利权人： National Health Research Institutes
- 当前专利权人地址： TW Miaoli County
- 代理机构： Occhiuti Rohlicek & Tsao LLP
- 主分类号： A01N43/90
- IPC分类号： A01N43/90 ; A61K31/519 ; A01N43/54 ; A61K31/505 ; C07D487/00 ; C07D491/00
摘要：
Fused bicyclic pyrimidine compounds of formula (I): wherein R1, R3, R4, X1, X2, Y, Z, A, B, C, D, n, and the two bonds are defined herein. Also disclosed are a method for inhibiting Aurora kinase activity and a method for treating cancer with these compounds.
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