发明授权
- 专利标题: Hepatitis C virus vaccine
- 专利标题(中): 丙型肝炎病毒疫苗
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申请号: US12396747申请日: 2009-03-03
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公开(公告)号: US08142794B2公开(公告)日: 2012-03-27
- 发明人: Emilio A. Emini , David C. Kaslow , Andrew J. Bett , John W. Shiver , Alfredo Nicosia , Armin Lahm , Alessandra Luzzago , Riccardo Cortese , Stefano Colloca
- 申请人: Emilio A. Emini , David C. Kaslow , Andrew J. Bett , John W. Shiver , Alfredo Nicosia , Armin Lahm , Alessandra Luzzago , Riccardo Cortese , Stefano Colloca
- 申请人地址: US NJ Rahway
- 专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人地址: US NJ Rahway
- 代理机构: McDonnell Boehnen Hulbert & Berghoff LLP
- 主分类号: C12N7/00
- IPC分类号: C12N7/00 ; C07H21/04
摘要:
The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against HCV.
公开/授权文献
- US20090233992A1 HEPATITIS C VIRUS VACCINE 公开/授权日:2009-09-17
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