Invention Grant
US08142826B2 Extract of Fraxinus excelsior seeds and therapeutic applications therefor
有权
Fraxinus提取物优良种子及其治疗应用
- Patent Title: Extract of Fraxinus excelsior seeds and therapeutic applications therefor
- Patent Title (中): Fraxinus提取物优良种子及其治疗应用
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Application No.: US12185649Application Date: 2008-08-04
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Publication No.: US08142826B2Publication Date: 2012-03-27
- Inventor: Kan He , Marc Roller , Antoine Bily , Naisheng Bai , Jacques Dikansky , Alvin Ibarra
- Applicant: Kan He , Marc Roller , Antoine Bily , Naisheng Bai , Jacques Dikansky , Alvin Ibarra
- Applicant Address: US NJ South Hackensack
- Assignee: Naturex, Inc.
- Current Assignee: Naturex, Inc.
- Current Assignee Address: US NJ South Hackensack
- Agency: Matthias Scholl, PC
- Agent Matthias Scholl
- Main IPC: A61K36/63
- IPC: A61K36/63

Abstract:
A Fraxinus excelsior seed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. The Fraxinus excelsior seed extract includes, inter alia, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl)methyl ester, commonly called excelside A, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl) 2-(4-hydroxyphenyl)ethyl ester, commonly called excelside B, and the compounds GI5, GI3, nuzhenide, and oleoside dimethyl ester.
Public/Granted literature
- US20090117214A1 Extract Of Fraxinus Excelsior Seeds And Therapeutic Applications Therefor Public/Granted day:2009-05-07
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