Invention Grant
US08142999B2 HLA alleles associated with adverse drug reactions and methods for detecting such
有权
与药物不良反应有关的HLA等位基因及其检测方法
- Patent Title: HLA alleles associated with adverse drug reactions and methods for detecting such
- Patent Title (中): 与药物不良反应有关的HLA等位基因及其检测方法
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Application No.: US13100665Application Date: 2011-05-04
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Publication No.: US08142999B2Publication Date: 2012-03-27
- Inventor: Yuan-Tsong Chen , Shuen-Iu Hung , Chih-Lung Shen , Chi-Feng Chang , Hsin-Yu Lin , Wei-Hsuan Chen
- Applicant: Yuan-Tsong Chen , Shuen-Iu Hung , Chih-Lung Shen , Chi-Feng Chang , Hsin-Yu Lin , Wei-Hsuan Chen
- Applicant Address: TW Taipei TW Taipei
- Assignee: Academia Sinica,Pharmigene, Inc.
- Current Assignee: Academia Sinica,Pharmigene, Inc.
- Current Assignee Address: TW Taipei TW Taipei
- Agency: Occhiuti Rohlicek & Tsao LLP
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34 ; C12M1/34
Abstract:
This invention relates to a method of determining the presence of certain HLA alleles, such as HLA-B*1502 or HLA-B*5801, and a kit for carrying out this method. Also disclosed is a method for assessing whether a patient is at risk for developing adverse drug reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis, or hypersensitivity syndrome) based on the presence or absence of a genetic marker (e.g., HLA-B*1502, HLA-B*5801, or HLA-B*4601).
Public/Granted literature
- US20110212439A1 HLA ALLELES ASSOCIATED WITH ADVERSE DRUG REACTIONS AND METHODS FOR DETECTING SUCH Public/Granted day:2011-09-01
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